Figure 1.

p27 is highly conserved between human and mouse. Comparison of human and mouse p27 sequences reveals they are 92% identical. Highlighted amino acids show absolute differences. Underlined amino acids indicate functional motifs: Cyclin E (RXL), CDK2 (FNF), Grb2 (PXXP) binding sites and the bipartite Nuclear Localization Signal (aa 152–166). Solid arrows show conserved phosphorylation sites. Blow up of Akt1 consensus site shows T157 is not maintained between species.