Cell Division
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  ReviewDisjunction of conjoined twins: Cdk1, Cdh1 and separation of centrosomesKaren Crasta  and Uttam Surana  Institute of Molecular and Cell Biology, Proteos, 61 Biopolis Drive, 138673, Singapore  author email corresponding author email
Cell Division 2006,
1:12doi:10.1186/1747-1028-1-12 Abstract
Accurate transmission of chromosomes from parent to progeny cell requires assembly of a bipolar spindle. Centrosomes (spindle pole body in yeast) are critical for the biogenesis of this complex mitotic apparatus since they confer bipolarity on the spindle and serve as the site of microtubule polymerization. In each division cycle, the centrosome is duplicated and the sister-centrosomes move away from each other, forming the two poles of the spindle. While the structure and the duplication of centrosomes have been investigated extensively, the understanding of the control of their segregation remains scant. Recent findings are beginning to yield insights into the regulation of centrosome segregation in yeast and its link to the mitotic kinase. | 
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