Rim15 and the crossroads of nutrient signalling pathways in Saccharomyces cerevisiae

doi:10.1186/1747-1028-1-3

Cell Division

Volume 1

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Swinnen E
Wanke V
Roosen J
Smets B
Dubouloz F
Pedruzzi I
Cameroni E
De Virgilio C
Winderickx J

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Wanke V
Roosen J
Smets B
Dubouloz F
Pedruzzi I
Cameroni E
De Virgilio C
Winderickx J
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Review

Rim15 and the crossroads of nutrient signalling pathways in Saccharomyces cerevisiae

Erwin Swinnen¹ , Valeria Wanke² , Johnny Roosen¹ , Bart Smets¹ , Frédérique Dubouloz² , Ivo Pedruzzi² , Elisabetta Cameroni² , Claudio De Virgilio² and Joris Winderickx¹

¹Functional Biology, Katholieke Universiteit Leuven, Kasteelpark Arenberg 31, B-3001 Leuven-Heverlee, Belgium

²Department of Microbiology and Molecular Medicine, CMU, University of Geneva, Geneva, Switzerland

author email corresponding author email

Cell Division 2006, 1:3doi:10.1186/1747-1028-1-3


Published:	3 April 2006

Abstract

In recent years, the general understanding of nutrient sensing and signalling, as well as the knowledge about responses triggered by altered nutrient availability have greatly advanced. While initial studies were directed to top-down elucidation of single nutrient-induced pathways, recent investigations place the individual signalling pathways into signalling networks and pursue the identification of converging effector branches that orchestrate the dynamical responses to nutritional cues. In this review, we focus on Rim15, a protein kinase required in yeast for the proper entry into stationary phase (G₀). Recent studies revealed that the activity of Rim15 is regulated by the interplay of at least four intercepting nutrient-responsive pathways.