Eg5 steps it up!
1 Department of Biological Sciences, Stanford University, Stanford CA 94305, USA
2 Department of Physics, Stanford University, Stanford CA 94305, USA
3 Department of Applied Physics, Stanford University, Stanford CA 94305, USA
Cell Division 2006, 1:31 doi:10.1186/1747-1028-1-31Published: 15 December 2006
Understanding how molecular motors generate force and move microtubules in mitosis is essential to understanding the physical mechanism of cell division. Recent measurements have shown that one mitotic kinesin superfamily member, Eg5, is mechanically processive and capable of crosslinking and sliding microtubules in vitro. In this review, we highlight recent work that explores how Eg5 functions under load, with an emphasis on the nanomechanical properties of single enzymes.