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Open Access Highly Accessed Review

Eg5 steps it up!

Megan T Valentine1, Polly M Fordyce2 and Steven M Block13*

Author Affiliations

1 Department of Biological Sciences, Stanford University, Stanford CA 94305, USA

2 Department of Physics, Stanford University, Stanford CA 94305, USA

3 Department of Applied Physics, Stanford University, Stanford CA 94305, USA

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Cell Division 2006, 1:31  doi:10.1186/1747-1028-1-31

Published: 15 December 2006

Abstract

Understanding how molecular motors generate force and move microtubules in mitosis is essential to understanding the physical mechanism of cell division. Recent measurements have shown that one mitotic kinesin superfamily member, Eg5, is mechanically processive and capable of crosslinking and sliding microtubules in vitro. In this review, we highlight recent work that explores how Eg5 functions under load, with an emphasis on the nanomechanical properties of single enzymes.