Figure 1.

Possible roles of αB-crystallin in SCF^Fbx4-Cyclin D1 complex assembly. A. αB-crystallin serves as a bridge between SCF^Fbx4 and Cyclin D1. B. αB-crystallin and Fbx 4 cooperatively bind Cyclin D1. C. The binding of αB-crystallin induces conformational change in Fbx4 that provides the structural basis for the complex formation.