Figure 2.

Functional domains in the Met4 protein. (A). Functional domains in the Met4 protein: ACT (activation domain), IR (Inhibitory Region), AUX (Auxiliary Region), BD (Basic Domain), LZ (Leucine Zipper), UIM (Ubiquitin Interacting Motif). Blue outlines functions associated with the domains. Green arrows point to cofactors interacting with the domains. Cofactors with a regulatory role are marked in green. DNA binding cofactors are marked in gray. Red horizontal arrows emphasize that new interactions could be created between cofactors when they bind to Met4. (B). Scheme illustrating dissociation of Met4 homodimers by SCF^Met30. See text for details.