Figure 2.

Mitotic chromosomal SUMOylation substrates. The distribution of SUMOylation substrates is schematically represented, based on the localization of the vertebrate homologues. (The localization reflects the bulk of each protein on mitotic vertebrate chromosomes, not specifically the SUMOylated forms.) The names of vertebrate proteins are indicated in black, while corresponding budding yeast proteins are given in red. In cases where SUMOylation has not been confirmed in both vertebrates and yeast, parentheses indicate the homologue for which demonstration is lacking. This representation does not include many proteins identified in proteomic screens [1-4] whose conjugation has not been independently verified, nor yeast proteins without obvious vertebrate homologues (e.g., Ndc10p, Cep3p [63]). Confirmed SUMOylation substrates associated to mitotic chromosomes (e.g., Histones [95]) are similarly not represented if the timing of their modification has not been demonstrated within the cell cycle.