Table 1

SUMO Pathway Enzymes

Enzymatic activity
Vertebrate
S. cerevisiae
S. pombe

SUMO paralogues
SUMO1
Smt3p
Pmt3p

SUMO2



SUMO3


SUMO protease
SENP1-3, SENP5-7
Ulp1p
Ulp1


Ulp2p/Smt4p
Ulp2
Activating Enzyme (E1)
Uba2/SAE2 +Aos1/SAE1
Uba2p+Aos1p
Uba2/Fub2 + Rad31
Conjugating Enzyme (E2)
Ubc9
Ubc9p
Hus5p
SP-RING SUMO ligases (E3)
PIAS1
Siz1p
Pli1

PIAS3
Siz2p/Nfi1p,


PIASxα



PIASxβ



PIASy



Mms21
Mms21p
Nse2p


Zip3p


Zimp7*



Zimp10*


Other SUMO ligases (E3)
RanBP2
(None known)
(None known)

Pc2



*Related to PIAS/Siz family, but SUMO ligase activity not been demonstrated in vitro.

Dasso Cell Division 2008 3:5   doi:10.1186/1747-1028-3-5