Table 1 |
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SUMO Pathway Enzymes |
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Enzymatic activity |
Vertebrate |
S. cerevisiae |
S. pombe |
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SUMO paralogues |
SUMO1 |
Smt3p |
Pmt3p |
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SUMO2 |
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SUMO3 |
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SUMO protease |
SENP1-3, SENP5-7 |
Ulp1p |
Ulp1 |
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Ulp2p/Smt4p |
Ulp2 |
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Activating Enzyme (E1) |
Uba2/SAE2 +Aos1/SAE1 |
Uba2p+Aos1p |
Uba2/Fub2 + Rad31 |
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Conjugating Enzyme (E2) |
Ubc9 |
Ubc9p |
Hus5p |
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SP-RING SUMO ligases (E3) |
PIAS1 |
Siz1p |
Pli1 |
|
PIAS3 |
Siz2p/Nfi1p, |
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PIASxα |
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PIASxβ |
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PIASy |
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Mms21 |
Mms21p |
Nse2p |
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Zip3p |
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Zimp7* |
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Zimp10* |
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Other SUMO ligases (E3) |
RanBP2 |
(None known) |
(None known) |
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Pc2 |
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*Related to PIAS/Siz family, but SUMO ligase activity not been demonstrated in vitro. |
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Dasso Cell Division 2008 3:5 doi:10.1186/1747-1028-3-5 |
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