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Mammalian H2A deubiquitinating enzymes (DUBs) |
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| DUB |
Domain structure |
Substrate |
Interactors |
Process |
Ref. |
|
|
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| USP3 |
ZnF-UBP, UCH |
H2A, H2B |
n.d. |
DNA damage response; S-phase progression |
[17] |
| USP16/UbpM |
ZnF-UBP, UCH |
H2A |
n.d. |
Transcription of HoxD10; G2/M transition |
[24,33] |
| USP21 |
UCH |
H2A |
n.d. |
Transcription |
[25] |
| USP22 |
ZnF-UBP, UCH |
H2A, H2B |
SAGA complex |
Transcriptional coactivator with Myc, AR, ER, GR; G1/S transition |
[28,29] |
| 2A-DUB/KIAA1915/MYSM1 |
SANT, SWIRM, JAMM/MPN+ |
H2A |
p/CAF, Trip5/KIF11, Rbm10 |
Transcriptional coactivator with AR |
[27] |
|
Abbreviations: ZnF-UBP, Zinc Finger-Ubiquitin Binding Domain; UCH, Ubiquitin C Terminal Hydrolase domain; AR, Androgen Receptor; ER, Estrogen Receptor; GR, Growth hormone Receptor; 2A-DUB, H2A DeUBiquitinase; JAMM, JAB1/MPN/Mov34 metalloenzyme domain; MPN+, Mpr1, Pad1 N-terminal + domain; p/CAF, p300/CBP Associated Factor; n.d., not determined. | |||||
Vissers et al. Cell Division 2008 3:8 doi:10.1186/1747-1028-3-8 |
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