|
Mammalian H2A E3 ubiquitin ligases |
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| E3 ligase |
Domain structure |
Substrate |
Interactors |
Process |
Ref. |
|
|
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| Ring1A/RING1, Ring1B/RNF2 |
RING |
H2A |
PRC1; E2F-6; Fbxl10/BcoR complexes |
Repression of transcription |
[11-14, 30-32,86,87] |
| RNF8 |
FHA, RING |
H2A/H2AX |
n.d. |
DNA damage response; G2/M transition |
[18,19,54,55,63,84,85] |
| 2A-HUB/KIAA0675/hRUL138/DZIP3 |
RING |
H2A |
N-CoR, HDAC1, HDAC3 |
Repression of specific chemokine genes |
[40] |
|
Abbreviations: PRC1, Polycomb Repressive Complex 1; Fbxl10, F-box and leucine-rich repeat protein 10 (JHD1B); BcoR, BCL6 co-repressor; RNF8, Ring Finger protein 8; FHA, forkhead-associated phosphopeptide-binding domain; N-CoR, Nuclear receptor Co-Repressor; HDAC, Histone De-Acetylase; n.d., not determined. | |||||
Vissers et al. Cell Division 2008 3:8 doi:10.1186/1747-1028-3-8 |
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