Figure 4.

Role of P-TEFb in a broad spectrum of biological processes. P-TEFb (blue pentagon) participates in many different biological processes, such as development (light orange oval), cancer (violet oval), cell cycle (yellow oval), cytokine response (pink oval) and others (green oval). Abbreviations in each oval represent particular transcription factors which have been found to employ P-TEFb in given biological phenomena (more information in the text). Importantly, dysregulation of P-TEFb-dependent transcription factors involved in development or cell cycle could also significantly contribute to malignant transformation of normal cells, as depicted by arrows in this figure.