Review
Proteomics, pathway array and signaling network-based medicine in cancer
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* Corresponding authors: David Y Zhang david.zhang@mssm.edu - Peng Lee peng.lee@nyumc.org
1 Department of Pathology, Mount Sinai School of Medicine, New York, NY, USA
2 Cancer Center, First Hospital of Jilin University, Changchun, PR China
3 Department of Pediatric Medicine, First Hospital of Jilin University, Changchun, PR China
4 Department of Gastrointestinal Medicine, Nanfang Medical University, Guangzhou, PR China
5 Department of Oncology, Shanghai Renji Hospital, Shanghai, PR China
6 Department of Gastrointestinal Medicine, First Hospital of Jilin University, Changchun, PR China
7 Department of Breast Surgery, First Hospital of Jilin University, Changchun, PR China
8 Department of Thoracic Surgery & Bethune Chest Center, First Hospital of Jilin University, Changchun, PR China
9 Department of Medicine, Mount Sinai School of Medicine, New York, NY, USA
10 NYU Cancer Institute, New York University School of Medicine, New York, NY, USA
11 Department of Pathology, New York University School of Medicine, New York, NY, USA
Cell Division 2009, 4:20 doi:10.1186/1747-1028-4-20
Published: 28 October 2009Additional files
Additional file 1:
Microarray technologies used in genomic and epigenetic analysis. Important features of genomic and epigenetic arrays.
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Additional file 2:
Comparison of different proteomics-based techniques. Advantage and disadvantages of various proteomic technologies.
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Additional file 3:
List of antibodies included in the immunoblot array (partial list). Relvant signaling proteins used in Pathway Array analysis.
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Additional file 4:
Effect of Cdk6 and XIAP silencing on cell viability, cell cycle distribution and necrosis. Example of functional relevance of signaling proteins.
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Additional file 5:
The expression of signaling transduction proteins in HCCs from 4 patients. Examples of the expression level of signaling proteins in HCC.
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