Cell Division

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Senescent mouse cells fail to overtly regulate the HIRA histone chaperone and do not form robust Senescence Associated Heterochromatin Foci

Alyssa L Kennedy1,2, Tony McBryan3, Greg H Enders2, F B Johnson4, Rugang Zhang2 and Peter D Adams3*

Author Affiliations

1 Graduate Program in Molecular and Cellular Biology and Genetics, Drexel University College of Medicine, Philadelphia, USA

2 Fox Chase Cancer Center, Philadelphia, USA

3 CR-UK Beatson Labs, Glasgow University, Glasgow, UK

4 University of Pennsylvania, Philadelphia, USA

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Cell Division 2010, 5:16 doi:10.1186/1747-1028-5-16

Published: 22 June 2010

Additional files

Additional file 1:

Figure S1: HIRA is not recruited to PML bodies in senescent MEFs. Localization of HIRA and PML in H-RasG12V transduced MEFs was analyzed by immunofluorescence.

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