Table 1 |
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|
Fission yeast F-box proteins |
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|
homologue |
SCF/ |
|||||
|
F-box protein |
motifs |
recognition protein |
yeast |
human |
*non-SCF |
References |
|
|
||||||
|
Pop1 |
WD40 |
Cig2, Cdc18, Rum1 |
Cdc4 |
Fbw7 |
SCF |
|
|
Pop2 |
WD40 |
Cig2, Cdc18, Rum1 |
Cdc4 |
Fbw7 |
SCF |
|
|
Pof1 |
WD40 |
Zip1 |
Met30 |
βTrCP |
SCF |
[47] |
|
Pof2 |
LRR |
Grr1 |
? |
SCF |
[25] |
|
|
Pof3 |
LRR, TPR |
Mcl1, Ams2 |
Dia2 |
? |
SCF |
|
|
Pof4 |
none |
Ela1 |
ElonginA |
SCF |
[25] |
|
|
Pof5 |
none |
YDR360c |
? |
SCF |
[25] |
|
|
Pof6 |
CAAX |
Rcy1 |
? |
non-SCF |
||
|
Pof7 |
none |
Hrt3 |
? |
SCF |
[25] |
|
|
Pof8 |
none |
Ufo1 |
? |
non-SCF |
||
|
Pof9 |
none |
YBR280c |
? |
SCF |
[51] |
|
|
Pof10 |
WD40 |
YML088w |
? |
SCF |
[52] |
|
|
Pof11 |
WD40 |
? |
βTrCP |
SCF |
[51]? |
|
|
Pof12 |
none |
? |
? |
non-SCF |
||
|
Pof13 |
none |
? |
? |
non-SCF |
||
|
Pof14 |
none |
Erg9 |
? |
? |
SCF |
[26] |
|
Fbh1 |
DNA helicase |
Atf1 |
? |
Fbh1 |
SCF |
|
|
SPAPB1A10.14 |
none |
? |
? |
SCF |
[51] |
|
|
|
||||||
|
*Assignment of some F-box proteins (Pof6, Pof8, Pof12 and Pof13) as 'non-SCF' is based upon the fact that these F-box proteins, albeit binding Skp1, do not have the conserved proline residue within the F-box motif that is critical for direct interaction between F-box and Cullin-1 [59]. In fact, binding experiments showed this is the case [51]. The only exception is Pof9, which does not contain the proline residue, but it acts as a component of SCF. |
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|
Takayama and Toda Cell Division 2010 5:18 doi:10.1186/1747-1028-5-18 |
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