Table 1

Fission yeast F-box proteins

homologue

SCF/

F-box protein

motifs

recognition protein

yeast

human

*non-SCF

References


Pop1

WD40

Cig2, Cdc18, Rum1

Cdc4

Fbw7

SCF

[30,34,46]

Pop2

WD40

Cig2, Cdc18, Rum1

Cdc4

Fbw7

SCF

[30,34,46]

Pof1

WD40

Zip1

Met30

βTrCP

SCF

[47]

Pof2

LRR

Grr1

?

SCF

[25]

Pof3

LRR, TPR

Mcl1, Ams2

Dia2

?

SCF

[25,28,48]

Pof4

none

Ela1

ElonginA

SCF

[25]

Pof5

none

YDR360c

?

SCF

[25]

Pof6

CAAX

Rcy1

?

non-SCF

[49,50]

Pof7

none

Hrt3

?

SCF

[25]

Pof8

none

Ufo1

?

non-SCF

[25,51]

Pof9

none

YBR280c

?

SCF

[51]

Pof10

WD40

YML088w

?

SCF

[52]

Pof11

WD40

?

βTrCP

SCF

[51]?

Pof12

none

?

?

non-SCF

[25,51]

Pof13

none

?

?

non-SCF

[25,51]

Pof14

none

Erg9

?

?

SCF

[26]

Fbh1

DNA helicase

Atf1

?

Fbh1

SCF

[53-58]

SPAPB1A10.14

none

?

?

SCF

[51]


*Assignment of some F-box proteins (Pof6, Pof8, Pof12 and Pof13) as 'non-SCF' is based upon the fact that these F-box proteins, albeit binding Skp1, do not have the conserved proline residue within the F-box motif that is critical for direct interaction between F-box and Cullin-1 [59]. In fact, binding experiments showed this is the case [51]. The only exception is Pof9, which does not contain the proline residue, but it acts as a component of SCF.

Takayama and Toda Cell Division 2010 5:18   doi:10.1186/1747-1028-5-18

Open Data