Commentary
Skp2 and Skp2B team up against Rb and p53
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Correspondence: Doris Germain doris.germain@mssm.edu
Mount Sinai School of Medicine, Tisch Cancer Institute, Division of Hematology/Oncology, One Gustave L. Levy Place, Box 1079, New York, New York 10029, USA
Cell Division 2011, 6:1 doi:10.1186/1747-1028-6-1
Published: 21 January 2011Abstract
The Skp2 locus encodes two proteins, Skp2 and Skp2B. The role of Skp2 in the ubiquitin-dependent degradation of key regulators of the retinoblastoma protein pathway has been well established. More recent work from the McCormick's group suggested that Skp2 has an ubiquitin-independent function in the regulation of the p53 pathway. Adding to this observation, we reported that Skp2B also regulates the activity of p53 by degrading a distinct substrate, prohibitin. Since prohibitin has been implicated in the regulation of the Rb pathway, collectively, these observations suggest that Skp2 and Skp2B team up against p53 and Rb.